Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats
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چکیده
منابع مشابه
Evaluation of Δ9-tetrahydrocannabinol metabolites and oxidative stress in type 2 diabetic rats
Objective(s): The object of the study is to examine the effects of Δ9-tetrahydrocannabinol (THC) against oxidative stress in the blood and excretion of THC metabolites in urine of type 2 diabetic rats. Materials and Methods: The control (n=8), THC control (n=6), diabetes (n=8) and diabetes + THC (n=7) groups were created. Type 2 diabetes was induced by nicotinamide (NA, 85 mg/kg) + streptozotoc...
متن کاملDetection of JWH-018 and JWH-073 by UPLC-MS-MS in postmortem whole blood casework.
Synthetic cannabinoids have been detected in various herbal blends sold legally in convenience stores, smoke shops, and on the Internet. Many of these compounds have extreme forensic significance. We developed and validated a rapid ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of trace concentrations of two of these compounds, JWH-018 and JWH-073,...
متن کاملSelf-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats
A recent study by Dr. Maria Antonietta De Luca demonstrated intravenous (IV) self-administration responding (nose-poking) for the synthetic cannabinoid JWH-018 [1-pentyl-3-(1-naphthoyl)indole] (Figure 1) in an experimentally naïve, adult rat species [1]. This finding is unexpected since the phytocannabinoid (−)-trans-Δ9tetrahydrocannabinol (Δ9-THC, Figure 1), a primary psychoactive constituent ...
متن کاملevaluation of δ9-tetrahydrocannabinol metabolites and oxidative stress in type 2 diabetic rats
objective(s): the object of the study is to examine the effects of δ9-tetrahydrocannabinol (thc) against oxidative stress in the blood and excretion of thc metabolites in urine of type 2 diabetic rats. materials and methods: the control (n=8), thc control (n=6), diabetes (n=8) and diabetes + thc (n=7) groups were created. type 2 diabetes was induced by nicotinamide (na, 85 mg/kg) + streptozotoc...
متن کاملConjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.
K2, a synthetic cannabinoid (SC), is an emerging drug of abuse touted as "legal marijuana" and marketed to young teens and first-time drug users. Symptoms associated with K2 use include extreme agitation, syncope, tachycardia, and visual and auditory hallucinations. One major challenge to clinicians is the lack of clinical, pharmacological, and metabolic information for the detection and charac...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2014
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2014.05.016